abstract：:BACKGROUND Liver cancer is a common malignant tumor with poor prognosis. The present study sought to identify potential signatures that can predict the prognosis of patients with liver cancer. MATERIAL AND METHODS The RNA sequencing (RNA-seq) and clinical information of liver cancer patients were obtained from the Can...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhang H,Zhuo C,Zhou D,Zhang M,Zhang F,Chen M,Xu S,Chen Z

更新日期：2020-02-09 00:00:00

abstract：:BACKGROUND The stability of orthodontic treatment is thought to be significantly affected by the compression and retraction of gingival tissues, but the underlying molecular mechanism is not fully elucidated. The objectives of our study were to explore the effects of mechanical force on the ECM-integrin-cytoskeleton l...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Wei L,Chen Q,Zheng Y,Nan L,Liao N,Mo S

更新日期：2020-02-08 00:00:00

abstract：:BACKGROUND Cerebral ischemia-reperfusion injury (CIRI) remains a serious health problem. Centella asiatica formulations are used to treat central nervous system disorders. In the present study, asiaticoside, an extract of the plant Centella asiatica, was investigated in CIRI in vivo and vitro. MATERIAL AND METHODS We ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhang C,Chen S,Zhang Z,Xu H,Zhang W,Xu D,Lin B,Mei Y

更新日期：2020-02-01 00:00:00

abstract：:BACKGROUND Alzheimer disease (AD) is a common and fatal subtype of dementia that remains a challenge to diagnose and treat. This study aimed to identify potential biomarkers that influence the prognosis of AD. MATERIAL AND METHODS A total of 6 gene expression profiles from the Gene Expression Omnibus (GEO) database we...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Liu L,Wu Q,Zhong W,Chen Y,Zhang W,Ren H,Sun L,Sun J

更新日期：2020-01-27 00:00:00

abstract：:BACKGROUND Whether type 2 diabetes mellitus (T2DM) is independently associated with structural heart abnormalities is controversial because of confounders associated with T2DM. This study aimed to investigate echocardiographic features in patients with newly diagnosed T2DM, exploring changes in cardiac structure and f...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhao Z,Hou C,Ye X,Cheng J

更新日期：2020-01-26 00:00:00

abstract：:BACKGROUND Osteoarthritis is a chronic degenerative disease of the joints that is common in older people worldwide. The characteristic features of osteoarthritis include cartilage degradation, synovitis, and remodelling of subchondral bone. The present study investigated the effect of 2-aminoquinoline on knee articula...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： He J,Zheng S

更新日期：2020-01-24 00:00:00

abstract：:BACKGROUND Competing risk analysis determines the probability of survival and considers competing events. This retrospective study aimed to undertake a competing risk analysis of prognosis in patients with esophageal carcinoma between 2006-2015 using data from the Surveillance, Epidemiology, and End Results (SEER) dat...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Yu Z,Yang J,Gao L,Huang Q,Zi H,Li X

更新日期：2020-01-22 00:00:00

abstract：:BACKGROUND In the present study, we aimed to evaluate early clinical and biochemical outcomes of direct anterior approach (DAA) versus posterolateral approach (PLA) for hemiarthroplasty in the treatment of displaced femoral neck fractures in geriatric patients. MATERIAL AND METHODS Between September 2012 and September...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Neyisci C,Erdem Y,Bilekli AB,Bek D

更新日期：2020-01-21 00:00:00

abstract：:BACKGROUND The habit of khat (Catha Edulis Forskal) chewing is widely practiced in the southern regions of Saudi Arabia, Yemen, and East Africa. This social habit has tremendous effects on oral and general health of khat chewers. Khat may affect bacterial species in plaque biofilms on oral rehabilitation materials. Th...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Al Moaleem MM,Porwal A,Al Ahmari NM,Shariff M,Homeida H,Khalid A

更新日期：2020-01-20 00:00:00

abstract：:BACKGROUND Carotid atherosclerosis (CA) is a common disease in middle-aged and elderly people, which is closely related to cardiovascular and cerebrovascular disease. In this study, we investigated the benefits of the electrocardiogram (ECG)-based R wave pulse wave index (ERWVI) for the diagnosis of CA. MATERIAL AND M...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zeng X,Zhu H,Liu W,Zhong J,Luo J

更新日期：2020-01-16 00:00:00

abstract：:BACKGROUND The function of long non-coding RNA (lncRNA) BMP/OP-responsive gene (BORG) has only been studied in breast cancer. We analyzed the role of BORG in colorectal cancer (CRC). MATERIAL AND METHODS BORG in CRC tissues and non-cancer tissues from 66 CRC patients was detected by performing quantitative reverse-tra...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Li J,Ma J,Zhang X,Tai X,Liu L,Zhang L

更新日期：2020-01-15 00:00:00

abstract：:BACKGROUND Circular RNAs (circRNAs), a newly-discovered class of non-coding RNAs, have a significant role in the progression of cancers, but the effect of hsa_circ_0086414 in human oral squamous cell carcinoma (OSCC) is still unclear. MATERIAL AND METHODS The circRNAs expression profile in OSCC tissue samples was asse...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Li L,Zhang ZT

更新日期：2020-01-14 00:00:00

abstract：:BACKGROUND Cervical cancer is a major threat to female health worldwide. This study was performed to study the anticancer potential of sclareol and as a chemo-sensitizing agent against human cervical cancer cells along with evaluating its effects on apoptosis, cell cycle arrest, and MAPK/ERK signaling pathway. MATERIA...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Li W,Ping Z,Xuemei G,Minglian L,Hongjuan M,Yi H,Zhongxiang Z

更新日期：2020-01-14 00:00:00

abstract：:BACKGROUND Although extracellular signal-regulated kinase 5 (ERK5) is known to be critical for osteoclast differentiation, there are few studies on how fluid shear stress (FSS) regulates osteoclast differentiation through the ERK5 signaling pathway. We examined the expression of nuclear factor of activated T cells c1 ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Ma C,Geng B,Zhang X,Li R,Yang X,Xia Y

更新日期：2020-01-08 00:00:00

abstract：:BACKGROUND The aim of this study was to investigate the clinical significance of NLRP3 and HMGB1 in patients with active ulcerative colitis. MATERIAL AND METHODS This was a prospective observational study which included a total of 62 cases with active ulcerative colitis during January 2017 to December 2018. The patien...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Chen Y,Wu D,Sun L

更新日期：2020-01-05 00:00:00

abstract：:BACKGROUND Lung cancer is one of the leading causes of mortality and morbidity. Viburnum grandiflorum is a medicinal herb known for its wide spectrum of pharmacological activities, but its anti-cancer properties against lung cancer cells have not been previously investigated. The present study elucidated the antitumor...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Han B,Wu J,Huang L

更新日期：2020-01-04 00:00:00

abstract：:BACKGROUND Despite noteworthy advancements in the multidisciplinary treatment of colorectal cancer (CRC) and deeper understanding in the molecular mechanisms of CRC, many of CRC patients with histologically identical tumors present different treatment response and prognosis. Thus, more evidence on novel predictive and...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Liu X,Bing Z,Wu J,Zhang J,Zhou W,Ni M,Meng Z,Liu S,Tian J,Zhang X,Li Y,Jia S,Guo S

更新日期：2020-01-01 00:00:00

abstract：:BACKGROUND Long non-coding RNAs (LncRNAs) could potentially function as diagnostic markers for gastric carcinoma. Nevertheless, the expression profile and biological feature of LncRNAs in early gastric cancer (EGC) remains to be explored. MATERIAL AND METHODS LncRNA expression microarray analysis was performed on 6 pa...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Yu H,Yang AM,Lu XH,Feng L,Wu X,Cui JF,Cheng JY

更新日期：2019-12-29 00:00:00

abstract：:BACKGROUND The aim of this study was to explore the effect of metformin by inducing autophagy for enhancing functional recovery of peripheral nerve in rats with sciatic nerve crush injury. MATERIAL AND METHODS Autophagy was determined by electron microscopy, immunofluorescence, and Western blot analysis. Motor functio...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Liu L,Tian D,Liu C,Yu K,Bai J

更新日期：2019-12-28 00:00:00

abstract：:BACKGROUND In an atherosclerotic artery wall, monocyte-derived macrophages are the principal mediators that respond to pathogens and inflammation. The present study aimed to investigate potential genetic changes in gene expression between normal tissue-resident macrophages and atherosclerotic macrophages in the human ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Wang W,Zhang K,Zhang H,Li M,Zhao Y,Wang B,Xin W,Yang W,Zhang J,Yue S,Yang X

更新日期：2019-12-25 00:00:00

abstract：:BACKGROUND Low back pain (LBP) is regarded as a frequent disease that causes disability. We aimed to explore the effect of naringin on intervertebral disc degeneration (IDD) in IL-1ß-induced human nucleus pulposus (NP) cells and its corresponding molecular mechanisms. MATERIAL AND METHODS

journal_title：Medical science monitor : international medical journal of experimental and clinical research